ARI-1 is a receptor tyrosine kinase-like orphan receptor 1 (ROR1) inhibitor. ARI-1 blocks the PI3K/AKT/mTOR signaling pathway in a ROR1-dependent manner. ARI-1 upregulates cleaved-PARP and p-P38. ARI-1 induces Apoptosis. ARI-1 has anticancer activity against non-small cell lung cancer[1].
Molecular Weight:
374.38
Purity:
99.16
Formula:
C20H22O7
Target:
Akt,Apoptosis,mTOR,PARP,ROR
Application Notes:
MCE Product type: Reference compound1
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