Afimetoran (BMS-986256) is an orally active, selective, and highly bioavailable TLR7/8 antagonist. Afimetoran (BMS-986256) can inhibit TLR7/8 activation of the NF-kappaB pathway and reverse TLR7 mediated resistance to steroid induced apoptosis in plasma cell like dendritic cells (pDCs). Afimetoran (BMS-986256) can be used for research on inflammation and autoimmune diseases (systemic lupus erythematosus)[1][2].
Molecular Weight:
444.57
Purity:
99.37
CAS Number:
[2171019-55-7]
Formula:
C26H32N6O
Target:
Apoptosis,NF-kappaB,Toll-like Receptor (TLR)
Application Notes:
MCE Product type: Reference compound
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