Colibactin 742, CAS [[2916559-62-9]] Preis auf Anfrage

Product Overview

• Article Name: Colibactin 742, CAS [[2916559-62-9]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-139621
• Supplier Catalog Number: HY-139621
• Alternative Catalog Number: MCE-HY-139621-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

Colibactin 742 is a covalently binding DNA-damaging agent targeting DNA, with an IC50 of 5.2 µM against human cervical cancer cells (HeLa). Colibactin 742 covalently binds to DNA, forming interstrand crosslinks (ICLs), activating the Fanconi anemia DNA repair pathway, inducing gammaH2AX and FANCD2 foci formation and cell cycle arrest, while exacerbating mismatch repair deficiency (MMRd)-related mutations. Colibactin 742 can mimic the genotoxicity of natural Colibactin while avoiding its instability, and is mainly used in colorectal cancer (CRC) related research, including microbial tumorigenesis mechanisms, DNA damage repair pathways, and mutation signature analysis[1][2][3].

Product Properties

• Molecular Weight: 742.91
• CAS Number: [2916559-62-9]
• Formula: C37H42N8O5S2
• Target: DNA Alkylator/Crosslinker

Application Notes

• Application Notes: MCE Product type: Reference compound