Donidalorsen (ISIS-721744, IONIS-PKK-LRX) sodium is an antisense oligonucleotide targeting prekallikrein (PKK). Donidalorsen sodium inhibits kallikrein activity and reduces the production of Bradykinin (HY-P0206) by specifically binding to and degrading PKK mRNA in the liver. Donidalorsen sodium can be used in the research of hereditary angioedema[1][2].
Molecular Weight:
8672.6 (free acid)
Purity:
95.90
CAS Number:
[2304701-45-7]
Formula:
C296H415N83Na20O151P20S15
Target:
Kallikrein
Application Notes:
MCE Product type: Oligonucleotides
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