ZYJ-34c is an orally active and potent histone deacetylase inhibitor (HDACi) with IC50s of 0.056 µM and 0.146 µM for HDAC6 and HDAC8, respectively. ZYJ-34c causes G1 phase arrest in low concentration. ZYJ-34c has antiproliferative activities. ZYJ-34c exhibits antitumor potency in MDA-MB-231 and HCT116 xenograft models and possesses antimetastatic potential in a mouse hepatoma-22 (H22) pulmonary metastasis model[1].
Molecular Weight:
582.69
CAS Number:
[1314556-93-8]
Formula:
C31H42N4O7
Target:
HDAC
Application Notes:
MCE Product type: Reference compound1
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