CSF1R-IN-3 (compound 21) is a potent and orally active CSF-1R inhibitor (IC50=2.1 nM). CSF1R-IN-3 is a potent antiproliferative activity against colorectal cancer cells. CSF1R-IN-3 inhibits the progression of colorectal cancer by suppressing the migration of macrophages, reprograming M2-like macrophages to the M1 phenotype, and enhancing the antitumor immunity[1].
Molecular Weight:
574.67
Purity:
98.10
CAS Number:
[2760584-90-3]
Formula:
C30H38N8O4
Target:
c-Fms
Application Notes:
MCE Product type: Reference compound
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