Pomalidomide-C5-Dovitinib, CAS [[2732969-67-2]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-139996
Supplier Catalog Number:
HY-139996
Alternative Catalog Number:
MCE-HY-139996-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC containing Pomalidomide, Dovitinib and connected with CRBN. Pomalidomide-C5-Dovitinib shows enhanced antiproliferative effects against FLT3-ITD+ AML cells. Pomalidomide-C5-Dovitinib induces the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely blocks their downstream signaling pathway. Pomalidomide-C5-Dovitinib has the potential for the research of FLT3-ITD+ acute myeloid leukemia[1].
