AS-99 is a first-in-class, potent, and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 µM, Kd= 0.89 µM) with anti-leukemic activity. AS-99 blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo[1].
Molecular Weight:
630.14
Formula:
C27H31ClF3N5O3S2
Target:
Apoptosis,Histone Methyltransferase
Application Notes:
MCE Product type: Reference compound
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