SIM1 is a potent von Hippel-Lindau (VHL)-based trivalent PROTAC capable of degradation for all BET family members, with preference for BRD2 degradation (IC50=1.1 nM, Kd=186 nM). SIM1 shows sustained anti-cancer activity[1].
Molecular Weight:
1618.81
Purity:
99.57
CAS Number:
[2719051-84-8]
Formula:
C79H98Cl2N14O13S3
Target:
Epigenetic Reader Domain,PROTACs
Application Notes:
MCE Product type: Reference compound
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