TBE 31 is a potent and orally active NQO1 inducer with an Dm value of 1.1 nM. TBE 31 also is a potent Nrf2 activator. TBE 31 reacts with cysteines of Keap1, impairing its ability to target nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) for degradation. TBE 31 shows cytoprotective effects[1][2].
Molecular Weight:
330.38
CAS Number:
[936475-62-6]
Formula:
C21H18N2O2
Target:
Keap1-Nrf2,Quinone Reductase
Application Notes:
MCE Product type: Reference compound
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