Tegaserod is an orally active serotonin receptor 4 (HTR4, 5-HT4R) agonist and a 5-HT2B receptor antagonist. Tegaserod has pKis of 7.5, 8.4 and 7.0 for human recombinant 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. Tegaserod causes tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. Tegaserod has anti-tumor activity and has the potential for irritable bowel syndrome (IBS) research[1][2][3].
Molecular Weight:
301.39
Purity:
99.71
CAS Number:
[145158-71-0]
Formula:
C16H23N5O
Target:
5-HT Receptor,Apoptosis
Application Notes:
MCE Product type: Reference compound
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