Nav1.7-IN-8 is a potent blockage of NaV1.7 with high selectivity for the inhibition of NaV1.7 over the subtypes hNaV1.1 and hNaV1.5. Nav1.7-IN-8 inhibits CYP2C9 and CYP3A4 with an IC50 of 0.17 µM and 0.077 µM, respectively. Nav1.7-IN-8 displays significant analgesic effects in rodent models of acute and inflammatory pain[1].
Molecular Weight:
535.93
CAS Number:
[1432913-44-4]
Formula:
C21H12ClF2N5O4S2
Target:
Cytochrome P450,Sodium Channel
Application Notes:
MCE Product type: Reference compound
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