cis-11,14-Eicosadienoic acid methyl ester is a more lipid soluble form of the omega-6 C20-2 fatty acid 11(Z),14(Z)-eicosadienoic acid, a naturally occurring PUFA. 11(Z),14(Z)-Eicosadienoic acid competitively inhibits inosine 5-monophosphate dehydrogenase (Ki=3.1 µM) and inhibits the binding of LTB4 to its receptor on neutrophils (Ki=3.0 µM). Also, serum levels of eicosadienoic acids negatively correlate with degree of sleep disturbance.3 Eicosadienoic acids are converted by desaturases, in vivo, to eicosatrienoic acids, which are potent vasodilators.
Molecular Weight:
322.53
CAS Number:
[61012-46-2]
Formula:
C21H38O2
Target:
Endogenous Metabolite
Application Notes:
MCE Product type: Reference compound1
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