ZA18 is a selective TRPM2 channel inhibitor, with an IC50 value of 6.2 µM. ZA18 can effectively suppress intracellular Ca2+ overload triggered by TRPM2 channel activation. ZA18 significantly reduce the mortality of SH-SY5Y cells induced by H2O2. ZA18 can be used for the study of ischemia-reperfusion injury, inflammation, or other neurodegenerative diseases[1].
Molecular Weight:
450.57
CAS Number:
[2696407-32-4]
Formula:
C29H30N4O
Target:
TRP Channel
Application Notes:
MCE Product type: Reference compound
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