MRK-560, a chemical probe, is an orally active, brain barrier-penetrated gamma-Secretase inhibitor, reducing Abeta peptide in rat brain and cerebrospinal fluid. MRK-560 decreases mutant NOTCH1 processing by selectively inhibiting PSEN1. MRK-560 can be used in studies of Alzheimers disease and T-cell acute lymphoblastic leukaemia (T-ALL)[1][2].
Molecular Weight:
517.92
Purity:
99.51
CAS Number:
[677772-84-8]
Formula:
C19H17ClF5NO4S2
Target:
gamma-secretase
Application Notes:
MCE Product type: Reference compound
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