di-Ellipticine-RIBOTAC, CAS [[2767983-76-4]] Preis auf Anfrage

Product Overview

• Article Name: di-Ellipticine-RIBOTAC, CAS [[2767983-76-4]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-141878
• Supplier Catalog Number: HY-141878
• Alternative Catalog Number: MCE-HY-141878-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

di-Ellipticine-RIBOTAC is a RNase recruiting chimera (RIBOTAC) degrader, capable of specifically binding and degrading expanded G4C2 RNA repeat (r(G4C2)exp). di-Ellipticine-RIBOTAC selectively binds the three-dimensional (3D) structure formed by r(G4C2)exp and that recruits an endogenous ribonuclease (RNase) to cleave r(G4C2)exp. di-Ellipticine-RIBOTAC selectively degrades the mutant chromosome 9 open reading frame 72 (C9orf72) allele and reduces quantities of toxic dipeptide repeat proteins (DPRs) translated from r(G4C2)exp. di-Ellipticine-RIBOTAC significantly improves the pathological phenotype of amyotrophic lateral sclerosis/ frontotemporal dementia (c9ALS/FTD) in cells and mouse models. di-Ellipticine-RIBOTAC can be used for the study of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)[1].

Product Properties

• Molecular Weight: 1410.63
• CAS Number: [2767983-76-4]
• Formula: C78H87N7O16S
• Target: DNA/RNA Synthesis

Application Notes

• Application Notes: MCE Product type: Reference compound