di-Ellipticine-RIBOTAC (TFA), CAS [[2767983-77-5]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-141878A
Supplier Catalog Number:
HY-141878A
Alternative Catalog Number:
MCE-HY-141878A-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
di-Ellipticine-RIBOTAC TFA is a RNase recruiting chimera (RIBOTAC) degrader, capable of specifically binding and degrading expanded G4C2 RNA repeat (r(G4C2)exp). di-Ellipticine-RIBOTAC TFA selectively binds the three-dimensional (3D) structure formed by r(G4C2)exp and that recruits an endogenous ribonuclease (RNase) to cleave r(G4C2)exp. di-Ellipticine-RIBOTAC TFA selectively degrades the mutant chromosome 9 open reading frame 72 (C9orf72) allele and reduces quantities of toxic dipeptide repeat proteins (DPRs) translated from r(G4C2)exp. di-Ellipticine-RIBOTAC TFA significantly improves the pathological phenotype of amyotrophic lateral sclerosis/ frontotemporal dementia (c9ALS/FTD) in cells and mouse models. di-Ellipticine-RIBOTAC TFA can be used for the study of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)[1].
Molecular Weight:
1524.65
CAS Number:
[2767983-77-5]
Formula:
C80H88F3N7O18S
Target:
DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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