3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles is an inhibitor for bone morphogenetic protein 2 (BMP2) with an IC50 of 2.2 µM. 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles is inhibitor for mitogen-activated protein kinase 1 (MEK1). 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles exhibits anti-inflammatory and neuroprotective activity in EAE mouse model[1][2].
Molecular Weight:
285.25
Purity:
99.84
CAS Number:
[287196-91-2]
Formula:
C11H6F3N3OS
Target:
MEK,TGF-beta/Smad
Application Notes:
MCE Product type: Reference compound
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