Siramesine (Lu 28-179) is a potent sigma-2 receptor agonist. Siramesine has a subnanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17 nM). Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity[1][2][3].
Molecular Weight:
454.58
Purity:
98.98
CAS Number:
[147817-50-3]
Formula:
C30H31FN2O
Target:
Sigma Receptor
Application Notes:
MCE Product type: Reference compound
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