TGR5 Receptor Agonist (CCDC), a potent Takeda G protein-coupled receptor 5 (TGR5, GPCR19) agonist, shows improved potency in the U2-OS cells and melanophore cells with pEC50s of 6.8 and 7.5, respectively. TGR5 Receptor Agonist can induce peripheral and central hypersensitivity to bladder distension in mice, and increase intracellular Ca2+ concentration. TGR5 Receptor Agonist can also reduces food intake and improves insulin responsiveness, in diet-induced obese mice. TGR5 Receptor Agonist can be used to research diabetes, bladder hypersensitivity and anti-obesity[1][2][3][4].
Molecular Weight:
361.22
Purity:
99.71
CAS Number:
[1197300-24-5]
Formula:
C18H14Cl2N2O2
Target:
Calcium Channel,G protein-coupled Bile Acid Receptor 1
Application Notes:
MCE Product type: Reference compound
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