HDAC-IN-27 (Compound 11h) is a potent, orally active class I HDAC-selective inhibitor with IC50 values ranging from 0.43 to 3.01 nM against HDAC1-3. HDAC-IN-27 exhibits both in vivo and in vitro antitumor activity. HDAC-IN-27 demonstrates significant anti-proliferative activity against acute myeloid leukemia (AML) cell lines by inducing apoptosis and histone acetylation (AcHH3 and AcHH4). HDAC-IN-27 can be used for research in acute myeloid leukemia (AML)[1].
Molecular Weight:
350.41
Purity:
98.12
CAS Number:
[2763368-89-2]
Formula:
C20H22N4O2
Target:
Apoptosis,HDAC
Application Notes:
MCE Product type: Reference compound
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