KR-39038 is an orally active and potent GRK5 (G protein-coupled receptor kinase 5) inhibitor, with an IC50 of 0.02 µM. KR-39038 significantly inhibits angiotensin II-induced cellular hypertrophy through suppression of HDAC5 pathway in neonatal cardiomyocytes. KR-39038 shows profound anti-hypertrophic effects and improved cardiac function. KR-39038 can be used for heart failure research[1].
Molecular Weight:
475.00
Purity:
99.68
CAS Number:
[2770300-35-9]
Formula:
C24H32ClFN6O
Target:
G Protein-coupled Receptor Kinase (GRK),HDAC
Application Notes:
MCE Product type: Reference compound
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