L-745870 is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. L-745870 shows weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and exhibits moderate affinity for 5-HT2 receptors, sigma sites and alpha-adrenoceptors[1][2][3].
Molecular Weight:
326.82
Purity:
99.92
CAS Number:
[158985-00-3]
Formula:
C18H19ClN4
Target:
Dopamine Receptor
Application Notes:
MCE Product type: Reference compound1
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