HL-8 is a PI3Kalpha PROTAC degrader. HL-8 promotes the ubiquitination and degradation of PI3Kalpha. HL-8 reduces pAKT levels. HL-8 has anticancer activity against colon and cervical cancer (Pink: PI3Kalpha ligand (HY-143277), Blue: E3 ligase VHL ligand (HY-138678), Black: linker (HY-W002042))[1].
Molecular Weight:
1144.27
Purity:
99.17
CAS Number:
[2766352-64-9]
Formula:
C57H59F2N11O9S2
Target:
Akt,PI3K,PROTACs
Application Notes:
MCE Product type: Reference compound
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