Itanapraced (CHF5074) is an orally active gamma-secretase modulator and a non-steroidal anti-inflammatory derivative. Itanapraced reduces Abeta42 and Abeta40 secretion with IC50 values of 3.6 and 18.4 µM, respectively. Itanapraced inhibits cell apoptosis of hippocampal neurons induced by oxygen and glucose deprivation (OGD). Itanapraced can be used for the research of Alzheimers disease[1][2].
Molecular Weight:
325.16
Purity:
99.37
CAS Number:
[749269-83-8]
Formula:
C16H11Cl2FO2
Target:
Apoptosis,gamma-secretase
Application Notes:
MCE Product type: Reference compound
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