Casopitant (GW679769) is a potent, selective, brain-penetrant and orally active neurokinin 1 (NK1) receptor antagonist. Casopitant antagonizes the emetic effects of Substance P (HY-P0201). Casopitant is also a substrate and weak to moderate inhibitor of CYP3A4. Casopitant is indicated for chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV)[1].
Molecular Weight:
616.61
CAS Number:
[414910-27-3]
Formula:
C30H35F7N4O2
Target:
Cytochrome P450,Neurokinin Receptor
Application Notes:
MCE Product type: Reference compound
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