DNMT3A-IN-1 (compound 1) is an effective and selective DNMT3A inhibitor. DNMT3A-IN-1 exhibits inhibitory activity against DNMT3A, with KI values ranging from 9.16 to 18.85 µM (AdoMet) and 11.37 to 23.34 µM (poly dI-dC). DNMT3A-IN-1 can induce apoptosis in acute myeloid leukemia (AML) cell lines (Apoptosis)[1][2].
Molecular Weight:
546.66
Purity:
99.94
CAS Number:
[1403598-56-0]
Formula:
C30H38N6O4
Target:
DNA Methyltransferase
Application Notes:
MCE Product type: Reference compound
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