ATR-IN-12 (Compound 5g) is a potent inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase with an IC50 value of 0.007 µM. ATR-IN-12 displays good anti-tumor activity and significantly reduces the phosphorylation level of ATR and its downstream signaling protein. ATR-IN-12 is a promising lead compound for subsequent agent discovery targeting ATR kinase[1].
Molecular Weight:
441.55
Formula:
C22H27N5O3S
Target:
ATM/ATR
Application Notes:
MCE Product type: Reference compound1
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