D18 is an immune modulator. D18 acts as a TLR7/8 dual agonist (EC50 = 24 nM for hTLR7 and 10 nM for hTLR8, respectively). D18 increases PD-L1 expression through epigenetic regulation, thus sensitizing tumors to PD-1/PD-L1 blockade. D18 is a ADC cytotoxin uesd for the systhesis of ADC HE-S2 (HY-144497). D18 has strong immune activation and anti-tumor activity. D18 commonly used in cancer research, such as colon cancer[1][2].
Molecular Weight:
364.49
Purity:
98.79
CAS Number:
[2230218-36-5]
Formula:
C21H28N6
Target:
PD-1/PD-L1,Toll-like Receptor (TLR)
Application Notes:
MCE Product type: Reference compound
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