Fatostatin hydrobromide (125B11 hydrobromide), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin hydrobromide binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin hydrobromide decreases the transcription of lipogenic genes in cells. Fatostatin hydrobromide possesses antitumor properties, and lowers hyperglycemia in ob/ob mice[1][2].
Molecular Weight:
375.33
Purity:
99.52
CAS Number:
[298197-04-3]
Formula:
C18H19BrN2S
Target:
Fatty Acid Synthase (FASN)
Application Notes:
MCE Product type: Reference compound1
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