GAT564 (Compound 15d) is a potent allosteric modulator of cannabinoid 1 receptor (CB1R) with EC50s of 87 and 320 nM respectively for cAMP and beta-arrestin2. GAT564 markedly promotes orthosteric ligand binding to hCB1R. GAT564 is efficacious as a topical agent that significantly reduces intraocular pressure (IOP) in the ocular normotensive murine model of glaucoma[1].
Molecular Weight:
348.42
CAS Number:
[2851895-01-5]
Formula:
C20H16N2O2S
Target:
Cannabinoid Receptor
Application Notes:
Reference compound
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