ASR-490 reduces the viability of HCT116 and SW620 cells by downregulating Notch1 signaling. ASR-490 overcomes Notch1 overexpression and inhibits the growth of HCT/Notch1 transfectants. ASR-490 inhibits the tumor growth in control (pCMV/HCT116) and Notch1/HCT116 in xenotransplanted mice[1].
Molecular Weight:
575.69
Purity:
99.20
CAS Number:
[2690312-67-3]
Formula:
C34H41NO7
Target:
Notch
Application Notes:
MCE Product type: Reference compound1
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