HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation. HQ461-mediated degradation of cyclin K impairs CDK12 function, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death[1].
Molecular Weight:
345.44
Purity:
98.10
CAS Number:
[1226443-41-9]
Formula:
C15H15N5OS2
Target:
CDK,Molecular Glues
Application Notes:
MCE Product type: Reference compound
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