RBN013209 is an orally active small molecule inhibitor of CD38 with an IC50 of 0.01 to 0.1 µM for human CD38. RBN013209 prevents the conversion of extracellular NAD+ to ADPR or cADPR in tumor cells and PBMCs. RBN013209 can be used in the study of tumor. In addition, RBN013209 enables CAR-T cells to maintain the naive state and central memory state, and decreases the expression of cell activation markers and exhaustion-related inhibitory receptors[1][2][3].
Molecular Weight:
384.43
Purity:
98.63
CAS Number:
[2597933-17-8]
Formula:
C19H24N6O3
Target:
CD38,LAG-3,PD-1/PD-L1,Tim3
Application Notes:
MCE Product type: Reference compound
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