NVP-DKY709 is an orally active and selective IKZF2 molecular glue degrader with the Dmax and DC50 of 53% and 4 nM, respectively. In addition, NVP-DKY709 can degrade IKZF4 (DC50: 13 nM) and SALL4 (DC50: 2 nM). NVP-DKY709 exerts anti-tumor activity by binding with CRBN to change conformation and recruit and degrade IKZF2[1][2].
Molecular Weight:
417.50
Purity:
99.66
CAS Number:
[2291360-73-9]
Formula:
C25H27N3O3
Target:
IKZF Family,Molecular Glues
Application Notes:
MCE Product type: Reference compound
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