NP3-146 (sodium), CAS [[1995068-96-6]]

Product Overview

• Article Name: NP3-146 (sodium), CAS [[1995068-96-6]]
• Biozol Catalog Number: MCE-HY-145087A
• Supplier Catalog Number: HY-145087A
• Alternative Catalog Number: MCE-HY-145087A-10MG,MCE-HY-145087A-100MG,MCE-HY-145087A-5MG,MCE-HY-145087A-25MG,MCE-HY-145087A-50MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

NP3-146 sodium is a NLRP3 inflammasome inhibitor through locking the NACHT domain of NLRP3. NP3-146 sodium shows potent inhibitory activity against IL-1beta release with an IC50 value of 0.171 µM in LPS (HY-D1056)/Nigericin (HY-127019)-stimulated BMDM cells. NP3-146 sodium regulates the levels of cleaved Caspase-1 and cleaved IL-1beta in cell supernatants. NP3-146 sodium can be used for the research of inflammatory diseases[1][2].

Product Properties

• Molecular Weight: 465.95
• Purity: 99.26
• CAS Number: [1995068-96-6]
• Formula: C20H27ClN2NaO5S
• Target: Caspase,Interleukin Related,NOD-like Receptor (NLR)

Application Notes

• Application Notes: MCE Product type: Reference compound