NCT-58 is a potent inhibitor of C-terminal HSP90. NCT-58 does not induce the heat shock response (HSR) due to its targeting of the C-terminal region and elicits anti-tumor activity via the simultaneous downregulation of HER family members as well as inhibition of Akt phosphorylation. NCT-58 kills Trastuzumab-resistant breast cancer stem-like cells. NCT-58 induces apoptosis in HER2-positive breast cancer cells[1].
Molecular Weight:
466.57
Purity:
99.63
CAS Number:
[2411429-33-7]
Formula:
C27H34N2O5
Target:
Apoptosis,HSP
Application Notes:
MCE Product type: Reference compound
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