UNC6934 is a selective NSD2-PWWP1 antagonist with IC50 values of 78 nM and 104 nM, and a Ka of 91 nM against human targets. UNC6934 binds to the canonical methyl-lysine binding pocket of NSD2-PWWP1 and directly competes with H3K36me2 for binding. UNC6934 induces the aggregation of NSD2 within the nucleolus, without altering ribosomal RNA transcription, global H3K36me2 levels or the proliferation of KMS-11 cells. UNC6934 can be used in studies related to multiple myeloma and diffuse intrinsic pontine glioma.[1][2]
Molecular Weight:
443.45
Purity:
99.15
CAS Number:
[2561494-77-5]
Formula:
C24H21N5O4
Target:
Histone Methyltransferase
Application Notes:
MCE Product type: Reference compound
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