Lometrexol (DDATHF), an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol has anticancer activity. Lometrexol also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor[1][2][3].
Molecular Weight:
443.45
Purity:
98.96
CAS Number:
[106400-81-1]
Formula:
C21H25N5O6
Target:
Antifolate,Apoptosis,Bcl-2 Family,Caspase
Application Notes:
Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
