BM213 is a selective C5aR agonist, with an EC50 of 59 nM. BM213 specifically activates the C5a-C5aR1 axis, which in turn promotes neutrophil extracellular trap (NET) formation and exacerbates inflammatory responses. BM213 significantly induces ventricular dilationin, promotes myocardial ROS production, and induces cardiomyocyte apoptosis in rats. BM213 can be used for the study of myocardial ischemia/reperfusion (I/R) injury[1].
Molecular Weight:
915.09
Purity:
99.81
CAS Number:
[2891606-02-1]
Formula:
C43H70N12O10
Target:
Apoptosis,Complement System,Reactive Oxygen Species (ROS)
Application Notes:
Reference compound
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