AL-GDa62 is a derivative of the CDH1/E-cadherin modulator SLEC-11 (HY-145268) and induces apoptosis in CDH1-/- cells. AL-GDa62 has an EC50 of 3.2 µM and 2 µM for isogenic mammary epithelial cells MCF10A-WT (wild type) and mutant MCF10A-CDH1-/-, respectively. AL-GDa62 specifically inhibits TCOF1, ARPC5, and UBC9, and suppresses SUMOylation at low micromolar concentrations[1].
Molecular Weight:
393.50
CAS Number:
[2761538-66-1]
Formula:
C24H28FN3O
Target:
Cadherin
Application Notes:
MCE Product type: Reference compound
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