APJ receptor agonist 5 (compound 3) is a potent and orally active agonist of apelin receptor (APJ) with an EC50 of 0.4 nM. APJ receptor agonist 5 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 5 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 5 leads to improved cardiac function and can be used for researching the HF disease[1].
Molecular Weight:
479.52
CAS Number:
[2135514-20-2]
Formula:
C26H29N3O6
Target:
Apelin Receptor (APJ)
Application Notes:
MCE Product type: Reference compound
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