CPT-Se3, a selenoproagent of Camptothecin (CPT), shows improved potency in killing cancer cells and inhibiting tumor growth. CPT-Se3 decreases the GSH/GSSG ratio and total thiols, elevates the ROS level in Hep G2 cells, and eventually induces apoptosis of cancer cells. CPT-Se3 shows cytotoxicity against HeLa, Hep G2, A549, and SMMC-7721 cells (IC50= 2.19-4.7 µM)[1].
Molecular Weight:
590.35
CAS Number:
[2968315-02-6]
Formula:
C24H20N2O6Se2
Target:
Apoptosis,Topoisomerase
Application Notes:
MCE Product type: Reference compound
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