CPT-Se4, a selenoproagent of Camptothecin (CPT), shows improved potency in killing cancer cells and inhibiting tumor growth. CPT-Se4 decreases the GSH/GSSG ratio and total thiols, elevates the ROS level in Hep G2 cells, and eventually induces apoptosis of cancer cells. CPT-Se4 shows cytotoxicity against HeLa, Hep G2, A549, and SMMC-7721 cells (IC50= 2.54-6.4 µM)[1].
Molecular Weight:
622.39
CAS Number:
[2968315-03-7]
Formula:
C25H24N2O7Se2
Target:
Apoptosis,Topoisomerase
Application Notes:
MCE Product type: Reference compound
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