Pelitrexol (AG 2037) is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), a purine biosynthetic enzyme. Pelitrexol also inhibits mTORC1 by reducing GTP-bound Rheb level, a mTORC1 obligate activator. Pelitrexol shows robust tumor growth suppression in mice[1].
Molecular Weight:
463.51
Purity:
98.07
CAS Number:
[446022-33-9]
Formula:
C20H25N5O6S
Target:
Antifolate
Application Notes:
MCE Product type: Reference compound
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