TTBK1-IN-2 (compound 29) is a potent Tau-Tubulin kinase (TTBK1) inhibitor with IC50s of 0.24 and 4.22 µM, respectively. TTBK1-IN-2 reveals good brain penetration in vivo and is able to reduce TDP-43 phosphorylation not only in cell cultures but also in the spinal cord of transgenic TDP-43 mice[1].
Molecular Weight:
336.78
Purity:
99.91
CAS Number:
[2765453-51-6]
Formula:
C18H13ClN4O
Target:
Tau Protein
Application Notes:
MCE Product type: Reference compound
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