Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively[1][2][3]. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM)[4].
Molecular Weight:
326.83
Purity:
99.84
CAS Number:
[5786-21-0]
Formula:
C18H19ClN4
Target:
5-HT Receptor,Adrenergic Receptor,Dopamine Receptor,Ligands for E3 Ligase,mAChR
Application Notes:
MCE Product type: Reference compound
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