Mitiperstat (AZD4831) is an effective oral inhibitor of myeloperoxidase (MPO). Mitiperstat inhibits MPO and thyroid peroxidase (TPO) with IC50s of 1.5 nM and 0.69 µM. Mitiperstat exhibits a weak inhibitory activity against CYP3A4 with an IC50 of 6 µM. Mitiperstat can reduce inflammation and improve microvascular function, and it can be used in studies related to heart failure, preserved or mildly reduced ejection fraction, non-alcoholic fatty liver disease, and chronic obstructive pulmonary disease[1][2][3][4].
Molecular Weight:
334.82
Purity:
99.12
CAS Number:
[1933460-19-5]
Formula:
C15H15ClN4OS
Target:
Cytochrome P450,Glutathione Peroxidase
Application Notes:
MCE Product type: Reference compound
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