TBPB (tert-butyl peroxybenzoate) is a highly selective, blood-brain-permeable M1 mAChR allosteric agonist (EC50=289 nM) with anti-schizophrenia and anti-inflammatory activities. TBPB can enhance the sensitivity of M1 receptors to acetylcholine, activate downstream signaling pathways, and inhibit the release of pro-inflammatory cytokines (TNF-alpha, IL-6). TBPB can regulate the processing of amyloid and can be used in the study of neurodegenerative diseases (such as Alzheimers disease) and inflammation-related diseases (such as sepsis)[1][2][3].
Molecular Weight:
404.55
Purity:
99.74
CAS Number:
[634616-95-8]
Formula:
C25H32N4O
Target:
Amyloid-beta,mAChR
Application Notes:
Reference compound
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