VU10010 is a potent, highly selective and allosteric M4 mAChR potentiator with an EC50 of 400 nM. VU10010 binds to an allosteric site on M4 mAChR and increases affinity for acetylcholine and coupling to G proteins. VU10010 increases carbachol-induced depression of transmission at excitatory but not inhibitory synapses in the hippocampus[1].
Molecular Weight:
345.85
Purity:
98.04
CAS Number:
[633283-39-3]
Formula:
C17H16ClN3OS
Target:
mAChR
Application Notes:
Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted